Effect of Cardio 360° - Prevent® on total, HDL- and LDL-cholesterol levels: a pre- and post-observational study


  • Giordano Zonzini
  • Alfredo Bressan
  • Brunella Radi
  • Cesare Gamberini
  • Marco Neri
  • Luca Boccoli
  • Iordanova Martina Tzvetanova
  • Davide Sisti




Hypercholesterolaemia, cardiovascular disease, Berberine, monacolin K, Poliferina®, Cardio 360°, Prevent®


Cardiovascular diseases (CVDs) are the leading cause of death globally. Hypercholesterolaemia, particularly low density lipoprotein (LDL) cholesterol, is directly involved in the atherosclerosis process. Consequentially, lowering cholesterolaemia and LDL-cholesterol serum levels will reduce cardiovascular risk. This observational study analyzed the results of 120 daily treatments with the food supplement (Cardio 360° - Prevent®) based on extracts of Ipomoea batatas, Crataegeus Laevigata, Berberis aristata, Olea europaea, Camellia sinensis and Polygonum cuspidatum in 25 individuals affected by mild hypercholesterolaemia. At the end of treatment, improvements were observed in total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL) and triglycerides (Trig.) serum levels when compared with baseline values. In particular, the supplementation of Cardio 360° - Prevent® was associated with a significant reduction in TC (-14.8 %), LDL (-19.3%) and triglycerides (-20.8%). A slight increase in HDL serum levels (+1.2%) was observed. Cardio 360° - Prevent® could be considered a new strategy and as an effective tool for the treatment of non-severe Dyslipidaemia, particularly mild hypercholesterolaemia. Further large-scale clinical trials are needed to evaluate efficacy, safety and tolerability to the mixtures of extracts used in clinical management of dyslipidaemias.