nutrafoods-international-journal-logo-80nutrafoods-international-journal-logo-80nutrafoods-international-journal-logo-80nutrafoods-international-journal-logo-80
  • HOME
  • NUTRAFOODS BOARD
  • ARTICLES
  • SUBMIT A MANUSCRIPT
  • CHECK STATUS

SHIME®: an advanced in vitro technology platform for studying the mode-of-action of probiotics in the gastrointestinal tract

The gastrointestinal microbiota plays a key role in human health. Over the past few decades, a lot of attention has been directed at improving health by modulating the gut microbial composition using probiotics. In vivo studies have limitations in providing mechanistic insights into the effect of probiotics and cannot be used to screen numerous test compounds. However, in vitro approaches can be used for mechanistic research under highly controlled environmental conditions. Here we describe how the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) can be used to produce data complementary to in vivo studies to help elucidate the mode-of-action of probiotics in the gastrointestinal tract.

DOI: 10.17470/NF-018-1023-4

DATE: 2018

AUTHOR/S: Duysburgh C, Van den Abbeele P, Marzorati M

ABSTRACT:
The gastrointestinal microbiota plays a key role in human health. Over the past few decades, a lot of attention has been directed at improving health by modulating the gut microbial composition using probiotics. In vivo studies have limitations in providing mechanistic insights into the effect of probiotics and cannot be used to screen numerous test compounds. However, in vitro approaches can be used for mechanistic research under highly controlled environmental conditions. Here we describe how the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) can be used to produce data complementary to in vivo studies to help elucidate the mode-of-action of probiotics in the gastrointestinal tract.

KEYWORDS:
SHIME®, Intestine, Microbiota, Health, Anti-pathogenic activity

 

10.17470/NF-018-1023-4

Download Article

Find a Specific Article

Find by Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016


ISSN 2240-5291 (electronic edition)

EDITORIAL INFORMATION

Editor-in-Chief
Francesco Di Pierro

Journal Office
Anna Lebovich

Mail: info@nutrafoods.eu

Copyright 2019 – Nutrafoods.eu

International Journal on Nutraceuticals, Functional Foods and Novel Foods
- from Research to Industrial Applications -


Privacy Policy  |  Cookies Policy
WebMaster KosmoSol
 
      By continuing to browse the site you are agreeing to our use of cookies.