Articles published in 2020

4 Maggio 2020
DOI: 10.17470/NF-020-0021

Supplementation with SEPIFITTM Protect, a complex of a natural red wine extract, vitamin E and zinc, improves exercise recovery in healthy men

Kern C, Garcia C
A period of intense or prolonged muscle activity can cause a decline in performance, which can range from muscle weakness to muscle damage and soreness. Muscle fatigue can be largely reversible in minutes or hours. It is generally viewed to be the result of insufficient energy and a lack of availability of key metabolites that enable contracting muscles to meet increased energy demand. However, muscle recovery can fail to take effect quickly, and this can be associated with structural changes and damage within the muscle, inducing a cascade of events leading to immediate or delayed soreness. In previous research, SEPIFIT TM Protect, a combination of natural red wine polyphenols, zinc and vitamin E, showed in vitro efficacy with respect to lactate, interleukin-6 and creatine kinase, which are markers of muscle damage and fatigue. We have therefore conducted a pilot clinical study to evaluate the effects of this active complex in healthy men undertaking regular and stable physical activity and who were subjected to a pain induction protocol. The results showed that the consumption of 135 mg of the complex per day for 12 days was effective in reducing creatine kinase release and maintaining muscular power capacity after the pain induction protocol. It also induced a better perception of performance, physical condition and muscle soreness. SEPIFIT TM Protect can thus be considered an interesting complex to contribute to muscle recovery during physical exertion.
30 Aprile 2020
DOI: 10.17470/NF-020-0020

Nutraceutical role of citrates in tissue pH balance: analysis and clinical interpretation of results obtained from urinary pH

Bertuccioli A, Rapacioli G, Ferrara T
Unbalanced diets with a high protein load, illness, abuse of drugs and ageing are some of the many elements predisposing to alter tissue pH balance. This, poorly compensated for by buffer systems acting to maintain the acid-base balance, can be a harbinger of: 1) calcium phosphate removal from the bones with osteopenia and, later, osteoporosis; 2) symptomatic aggravation of various pre-existing conditions typically characterized by the presence of pain (arthritis, headache, myalgia and so on); 3) the genesis of new diseases. The scientific literature clearly reports that the administration of citrates, or carbonates, support physiological pH tissue balance and alkalizes urinary pH. In addition, this effect, could reduce the risk of osteopenia and the perception of pain. Non-allopathic medicine describes a situation that is even more severe, secondary to that described above. Wit the progression of impaired balance, the body, probably in an attempt to limit the damage to skeleton structures, could bring about the storage of excess acid in the extracellular matrix by preventing its further elimination in urine, which would then be paradoxically alkaline. The aim of our study was to demonstrate that, even in this case, the administration of citrates can normalize urinary pH, making it acidic. This urinary normalization would be the result of the release of stored acid from connective tissue. This release would also lead to balance tissue pH and this would be monitored through observing the typical symptoms of patients with osteoarthritis, myalgia, headache and migraine, the incidence of which should be significantly reduced.
15 Aprile 2020
DOI: 10.17470/NF-020-0019

The oral intake of specific Bioactive Collagen Peptides has a positive effect on hair thickness

Oesser S
The effectiveness of supplementation with Bioactive Collagen Peptides (BCP) on the health and appearance of the skin and nails has been proven in several clinical trials. The influence of BCP supplementation on hair, however, has not been investigated to the same extent. In this placebo-controlled study, therefore, the effects of BCP intake on hair thickness and metabolism were investigated. The study was conducted on 44 healthy women aged between 39 and 75, who each received a daily dosage of 2.5 g BCP or placebo. After a treatment period of 16 weeks, hair thickness was determined and compared with the thickness at the beginning of the trial. In addition, the proliferation rate of human hair follicle cells that had been exposed to BCP was examined and the results compared with untreated control cells. The data showed a statistically significant (p<0.01) increase in the cell proliferation rate of 31% compared to the controls. The measurement of hair thickness showed a statistically significant (p<0.01) increase in the BCP group compared to placebo. Over the course of the collagen peptide treatment, hair thickness increased significantly by 1.93 ± 0.42 μm (p<0.01), whereas a slight decrease in hair thickness of -0.99 ± 0.40 μm (p=0.07) was measured in the placebo group. This clearly demonstrates the positive effect of BCP treatment on hair thickness and follicle cell proliferation.
27 Marzo 2020
DOI: 10.17470/NF-020-0018

Positive effect of fish-derived Bioactive Collagen Peptides on skin health

Proksch E, Schunck M, Oesser S
The positive effect of orally administered collagen peptides on skin health has been demonstrated in several clinical trials. In this placebo-controlled study, the impact of specific fish-derived Bioactive Collagen Peptides (BCP) on skin elasticity and wrinkle reduction was investigated. A total of 76 Asian and Caucasian women (62.2 ± 8.2 years of age) received a daily dosage of 5 g BCP or placebo. Skin elasticity and changes in eye wrinkle volume were evaluated at the beginning of the study, after 4 and 8 weeks of treatment and 4 weeks after the last intake (regression phase). In a subgroup analysis, differences between the results for Asian and Caucasian participants were investigated. The data showed a statistically significant (p<0.05) improvement in skin elasticity after only 4 weeks of BCP supplementation, compared with placebo. This positive effect persisted after 8 weeks of supplementation, and 4 weeks after BCP intake was stopped (p<0.05). Wrinkle volume was also reduced in a statistically significantly (p<0.05) manner after BCP treatment, compared to placebo. A pronounced decrease in eye wrinkle volume could be determined 4 weeks after BCP treatment commenced. After 8 weeks, a wrinkle reduction of 15% was observed and the efficacy of the treatment was confirmed at the end of the regression phase (p<0.05). The subgroup analysis revealed no statistically significant differences. The BCP treatment was effective in both Asian and Caucasian subjects. The results clearly demonstrated the efficacy of orally administered fish-derived BCP on skin health.