Phenolic content and antioxidant activity of solvent extracts of mahua (Madhuca longifolia) flowers and fruit
Infectious diseases remain a major health challenge and are becoming increasingly difficult to manage due to the spread of antibiotic resistance. A novel approach is to exploit human milk oligosaccharides (HMOs), which are now known to reduce the prevalence of infectious diseases among breastfed infants. HMOs have bacteriostatic or bactericidal activity against a wide range of important pathogens, such as Streptococcus agalactiae (group B Streptococcus), Streptococcus pneumoniae, Campylobacter jejuni, Clostridioides difficile, Entamoeba histolytica and Candida albicans. Furthermore, HMOs can act synergistically with antibiotics, reducing the minimum inhibitory concentration for certain antibiotics by up to 32-fold. This could extend the therapeutic window of some antibiotics and also reduce the doses required to treat infectious diseases. Given the risk posed by the emergence of antibiotic-resistant pathogens, it would be advantageous to further exploit this synergism between antibiotics and HMOs.
AUTHOR/S: Singh V, Mishra S, Singh J, Ray A.K.
ABSTRACT: Background: The aim of this study was to investigate the antioxidant activity of ethanol, acetone, methanol and water extracts of fresh mahua (Madhuca longifolia) flowers and fruit. Antioxidant potential was examined by measuring total phenolic content (TPC), total flavonoid content (TFC) and total antioxidant capacity using the 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH) radical scavenging assay and the Trolox equivalent antioxidant capacity (TEAC) assay. Results: The highest and lowest phenol and flavonoid contents were found in the acetone and water extracts, respectively. The antioxidant activity of mahua flowers and fruit measured by different assays were higher in the acetone extract compared to the other solvent extracts (acetone extract>methanol extract>ethanol extract>water extract). Conclusion: The results indicate that the flowers and fruit of mahua are good sources of polyphenols and natural antioxidants and could be useful as functional food ingredients beneficial for human health.